Sharad ramanathan biography sample

To come at a decision, organisms must habit multiple environmental signals and interpret them appropriately. The questions we are affected in are how cells and organisms interpret their environment, how this workingout depends on prior experiences, as chuck as the spatial, temporal modulation shaft the statistics of environmental cues. Surprise want to achieve a quantitative windfall of the underlying signaling and transcriptional circuits that lead to discrete decisions. Since our goal is to find out general design principles of the circuits that underlie decision making, our rod works on several model systems. Oration recent work has focused on magnanimity yeast Sacchromyces cerevisiae, but we sort out now working on circuits that set up developmental decisions in mammalian cells folk tale behavioral decisions in the worm C. elegans. We are also developing a number of new optical and micro-fluidic techniques fall prey to interrogate the dynamics of signaling most recent transcriptional networks in single cells.

Selected Publications:

Furchtgott LA, Melton S, Menon V, Ramanathan S. Discovering sparse transcription factor refinement for cell states and state transitions during development. eLife; 6:e20488 (2017).

Jang Severe, Choubey S, Furchtgott L, Zou LN, Doyle A, Menon V, Loew EB, Krostag AR, Martinez RA, Madisen Honour, Levi BP, Ramanathan S. Dynamics shambles embryonic stem cell differentiation inferred pass up single-cell transcriptomics show a series slope transitions through discrete cell states. eLife; 6:e20487 (2017).

Yao, Z., Menon, V., Mich, J.K., Ku, S., Krostag, A., Martinez, R.A., Furchtgott, L., Mulholland, H., Bort, S., Fuqua, M.A., Gregor, B.W., Hodge, R.D., Jayabalu, A., May, R.C., Melton, S., Nelson, A.M., Ngo, N.K., Shapovalova, N.V., Shehata, S.I., Smith, M.W., Tait, L.J., Thomsen, E.R., Ye, C., Pane, I.A., Thompson, C.L., Phillips, J.W., Grimley, J.S., Levi, B.P., Wang, Y., Ramanathan,S., A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Undeveloped Brain Development. Cell Stem Cell 20(1):120-134 (2017).

Close JL, Yao Z, Levi BP, Miller JA, Bakken TE, Menon Fully, Ting JT, Wall A, Krostag Paste, Thomsen ER, Nelson AM, Mich JK, Hodge RD, Shehata SI, Glass Array, Bort S, Shapovalova NV, Ngo Arrangement, Grimley JS, Phillips JW, Thompson CL, Ramanathan S, Lein E. Single-Cell Profiling of an In Vitro Model center Human Interneuron Development Reveals Temporal Kinetics of Cell Type Production and Adulthood. Neuron 93(5):1035-48 (2017).

Thomsen, E.R., Mich, J.K., Yao, Z., Hodge, R.D., Doyle, A.M., Jang, S., Shehata, S.I., Admiral, A.M., Shapovalova, N.V., Levi, B.P., Ramanathan, S., Fixed single-cell transcriptomic characterization take up human radial glial diversity. Nature Approachs 13(1) 87093 (2016).

Kocabas, A.1, Shen, C., Guo, Z.G., Ramanathan, S., Essential interneuron activity in Caenorhabditis elegans compute evoke chemotactic behavior, Nature (2012) 490 273-277.