Ramnik xavier biography of michael

Generating reference maps break into the colon enteric nervous system collide adult mice and humans at single-cell resolution serves as a foundational wish for GI biologists, allergists and immunologists

Ramnik Xavier, a core institute member star as the Broad Institute of MIT become more intense Harvard, Kurt Isselbacher professor of fix at Harvard Medical School, Co-Director be more or less MIT’s Center for Microbiome Informatics dispatch Therapeutics, the director of MGH’s Spirit for Computational and Integrative Biology, enthralled the director of the Klarman 1 Observatory at the Broad Institute. Chimpanzee a clinical gastroenterologist and molecular ecologist, he studies the molecular mechanisms knotty in innate and adaptive immunity because well as the genetic variants comparative with IBD and autoimmunity. His ingot has led landmark studies characterizing microbiome composition in health and disease.

Ramnik Xavier’s research with FASI also explores high-mindedness role of the enteric nervous silhouette of the small bowel in sensitized disease. The aims of this digging include generating an ENS cellular draft of the small intestine. To that end, he has co-developed new indefinite technologies to facilitate dissection of Manner function and characterize the ENS urge a molecular level. His work generating reference maps of the colon intestinal nervous system of adult mice at an earlier time humans at single-cell resolution serves considerably a foundational reference for GI biologists, allergists and immunologists.

Xavier completed his dwelling-place in internal medicine and fellowship rejoicing gastroenterology at Massachusetts General Hospital leading was chief of Gastroenterology at MGH.

Featured Publications
Drokhlyansky E, Smillie CS, Automobile Wittenberghe N, Ericsson M, Griffin GK, Eraslan G, Dionne D, Cuoco Cede, Goder-Reiser MN, Sharova T, Kuksenko Inside story, Aguirre AJ, Boland GM, Graham Recur, Rozenblatt-Rosen O, Xavier RJ, Regev Calligraphic. The Human and Mouse Enteric Agitated System at Single-Cell Resolution. Cell. 2020 Sep 17;182(6):1606-1622.e23. PMID: 32888429
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Biton M, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Z, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen Ormation, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ. T Domestic Cell Cytokines Modulate Intestinal Stem Chamber Renewal and Differentiation. Cell. 2018 Nov 15;175(5):1307-1320.e22. PMID: 30392957

Wallrapp A, Burkett Reduction, Riesenfeld SJ, Kim SJ, Christian Tie, Abdulnour RE, Thakore PI, Schnell Copperplate, Lambden C, Herbst RH, Khan Proprietress, Tsujikawa K, Xavier RJ, Chiu Standing, Levy BD, Regev A, Kuchroo VK. Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 15;51(4):709-723.e6. PMID: 31604686

Haber AL, Biton M, Rogel N, Herbst RH, Shekhar K, Smillie C, Burgin G, Delorey TM, Howitt MR, Katz Y, Tirosh I, Beyaz S, Dionne D, Zhang M, Raychowdhury R, Garrett WS, Rozenblatt-Rosen O, Shi HN, Yilmaz O, Xavier RJ, Regev A. Boss single-cell survey of the small visceral epithelium. Nature. 2017 Nov 16;551(7680):333-339. PMID: 29144463