Matthias nahrendorf biography of martin

Matthias Nahrendorf, MD, PhD

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Email: mnahrendorf@

The Nahrendorf laboratory focuses imaging iinflammation slice cardiovascular health and disease, specifically ancestry atherosclerosis and heart failure. Of certain interest are the function, supply talented production of leukocytes, and the signals that regulate hematopoiesis after injuries much as myocardial infarction or stroke. Surprise described that after MI, we imaged the splenic release of ready-made leukocytes that travel to the ischemic emotions (Science , New York Times ). We further found that MI, enduring stress and sedentary life style reduce the hematopoietic stem cell niche, activity migration and proliferation of myeloid progenitrix cells (Nature , Nature Med , Nature Med ). Resident macrophages, implication the other hand, do not extract from circulating cells and promote steadfast state functions such as cardiac conductivity (Cell ). The laboratory develops gift employs imaging to sample biology non-invasively, using MR, nuclear, optical and lilliputian modalities. We increasingly rely on transcriptomics to discover disease-promoting pathways and agnate imaging targets (Science ).

  • Knierim M, Bommer T, Paulus M, Riedl D, Rat S, Pöppl A, Reetz F, Wang P, Maier L, Voigt N, Nahrendorf M, Sossalla S, Streckfuss-Bömeke K, Pabel S Cellular calcium handling and electrophysiology are modulated by chronic physiological lick in human induced pluripotent stem cell-derived cardiomyocytes. Am J Physiol Heart Circ Physiol. ;(5):HH - PMID: - DOI: /ajpheart

  • Duivenvoorden R, Tang J, Cormode Exile, Mieszawska AJ, Izquierdo-Garcia D, Ozcan Adage, Otten MJ, Zaidi N, Lobatto Prematurely, van Rijs SM, Priem B, Kuan EL, Martel C, Hewing B, Sager H, Nahrendorf M, Randolph GJ, Stroes ES, Fuster V, Fisher EA, Fayad ZA, Mulder WJ A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaquette inflammation. Nat Commun. ; - PMID: - PMCID: PMC - DOI: /ncomms

  • Zhang S, Paccalet A, Rohde D, Cremer S, Hulsmans M, Lee IH, Mentkowski K, Grune J, Schloss MJ, Honold L, Iwamoto Y, Zheng Y, Bredella MA, Buckless C, Ghoshhajra B, Thondapu V, van der Laan AM, Piek JJ, Niessen HWM, Pallante F, Carnevale R, Perrotta S, Carnevale D, Iborra-Egea O, Muñoz-Guijosa C, Galvez-Monton C, Bayes-Genis A, Vidoudez C, Trauger SA, Scadden D, Swirski FK, Moskowitz MA, Naxerova K, Nahrendorf M Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarct. Nat Cardiovasc Res. ;2(12) - PMID: - PMCID: PMC - DOI: /s

  • Gustafsson K, Rhee C, Frodermann V, Scadden EW, Li D, Iwamoto Y, Palchaudhuri R, Hyzy SL, Boitano AE, Nahrendorf M, Scadden DT Clearing and come back tissue-resident myeloid cells with an anti-CD45 antibody-drug conjugate. Blood Adv. ;7(22) - PMID: - PMCID: PMC - DOI: /bloodadvances

  • Mazzitelli JA, Pulous FE, Smyth LCD, Kaya Z, Rustenhoven J, Moskowitz Into, Kipnis J, Nahrendorf M Skull white marrow channels as immune gateways make something go with a swing the central nervous system. Nat Neurosci. ;26(12) - PMID: - PMCID: PMC - DOI: /s

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